Yasushi Matsumura Selected Research

Oral Administration

5/2015

KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration.

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Yasushi Matsumura Research Topics

Disease

8	Cardiomegaly (Heart Hypertrophy) 05/2007 - 01/2002
6	Hypertrophy 01/2008 - 01/2002
4	Heart Failure 10/2020 - 10/2004
4	Infections 02/2005 - 01/2002
3	Myocardial Infarction 04/2013 - 04/2003
2	Neoplasms (Cancer) 04/2020 - 01/2008
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/2007 - 10/2004
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 05/2005 - 03/2002
1	Stroke (Strokes) 04/2020
1	Cancer Pain 07/2019
1	Drug-Related Side Effects and Adverse Reactions 01/2018
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2018
1	Carcinogenesis 05/2015
1	Colitis 05/2015
1	Ulcerative Colitis 05/2015
1	Liver Diseases (Liver Disease) 05/2011
1	Fibrosis (Cirrhosis) 05/2005
1	Body Weight (Weight, Body) 05/2005
1	Coinfection 02/2005
1	Melanoma (Melanoma, Malignant) 04/2004
1	Ventricular Remodeling 12/2003
1	Experimental Melanoma 12/2003
1	Miosis 12/2003
1	Infarction (Infarctions) 04/2003
1	Ischemia 02/2003

Drug/Important Bio-Agent (IBA)

7	MAP Kinase Kinase Kinase 5IBA 01/2008 - 01/2002
5	Phosphotransferases (Kinase)IBA 07/2007 - 02/2003
4	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2005 - 01/2002
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 02/2005 - 01/2002
4	NF-kappa B (NF-kB)IBA 02/2005 - 01/2002
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2004 - 01/2002
2	Pharmaceutical PreparationsIBA 07/2019 - 01/2018
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008 - 02/2002
2	AntioxidantsIBA 05/2005 - 03/2002
2	Messenger RNA (mRNA)IBA 05/2005 - 03/2002
2	p38 Mitogen-Activated Protein KinasesIBA 05/2005 - 02/2003
2	Angiotensin IIIBA 10/2004 - 01/2002
2	Endothelin-1 (Endothelin 1)IBA 06/2004 - 01/2002
2	3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy - 1- butenyl)- 3,5- dihydroxycyclopentyl)- 5- heptenoic acid (5Z)-7-((1R,2RIBA 04/2004 - 12/2003
2	Latanoprost (Xalatan)FDA Link 04/2004 - 12/2003
2	Melanins (Melanin)IBA 04/2004 - 12/2003
2	tafluprostIBA 04/2004 - 12/2003
2	NF-KappaB Inhibitor alphaIBA 06/2003 - 01/2002
1	pro-brain natriuretic peptide (1-76)IBA 10/2020
1	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2020
1	Dextran SulfateIBA 05/2015
1	Dinoprostone (PGE2)FDA Link 05/2015
1	KAG-308IBA 05/2015
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 05/2015
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2013
1	Lymphotoxin-alpha (Lymphotoxin)IBA 04/2013
1	4-hydroxy-2-nonenal (4-hydroxynonenal)IBA 01/2009
1	IronIBA 01/2009
1	ferric ferrocyanide (Prussian blue)FDA Link 01/2009
1	8-Hydroxy-2'-DeoxyguanosineIBA 01/2009
1	Oxygen (Dioxygen)IBA 08/2008
1	Hemoglobins (Hemoglobin)IBA 08/2008
1	CalpainIBA 07/2007
1	DystrophinIBA 07/2007
1	Proteins (Proteins, Gene)FDA Link 05/2007
1	Protein Kinases (Protein Kinase)IBA 05/2005
1	Atrial Natriuretic Factor (ANF)IBA 05/2005
1	EdaravoneIBA 05/2005
1	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 02/2005
1	KN 93IBA 02/2005
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2004
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 10/2004
1	Focal Adhesion Kinase 2IBA 06/2004
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 06/2004
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 06/2004
1	PhXa 85IBA 04/2004
1	prostaglandin F2alpha receptorIBA 04/2004
1	AFP-157IBA 12/2003
1	3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy - 1- butenyl)- 3,5- dihydroxycyclopentyl)- 5- heptenoate 1-ethyl (5Z)-7-((1R,2RIBA 12/2003
1	3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy - 1- butenyl)- 3,5- dihydroxycyclopentyl)- 5- heptenoate 1-methyl (5Z)-7-((1R,2RIBA 12/2003
1	Carboxylic AcidsIBA 12/2003
1	EstersIBA 12/2003
1	Carrier Proteins (Binding Protein)IBA 06/2003
1	Guanine NucleotidesIBA 06/2003
1	rac1 GTP-Binding ProteinIBA 06/2003
1	C-Reactive ProteinIBA 04/2003
1	Mitogen-Activated Protein Kinase 14IBA 02/2003
1	CalciumIBA 01/2003
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 03/2002
1	Heme Oxygenase-1IBA 03/2002
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 01/2002
1	Heparin (Liquaemin)FDA LinkGeneric 01/2002
1	Metalloproteases (Metalloproteinases)IBA 01/2002
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 01/2002
1	KB R7785IBA 01/2002
1	ErbB Receptors (EGF Receptor)IBA 01/2002
1	Epidermal Growth Factor (EGF)IBA 01/2002

Therapy/Procedure

3	Therapeutics 07/2007 - 01/2002
1	Drug Therapy (Chemotherapy) 04/2020
1	Polypharmacy 07/2019
1	Oral Administration 05/2015
1	Contraindications 05/2011
1	Ligation 08/2008